Bileaflet Prosthesis Design and Orientation Affect Fluid Shear, Residence Time, and Thrombus Formation

Vi Vu; Karen May-Newman

doi:10.1053/j.jvca.2019.03.018

Bileaflet Prosthesis Design and Orientation Affect Fluid Shear, Residence Time, and Thrombus Formation

J Cardiothorac Vasc Anesth. 2019 Oct;33(10):2870-2872. doi: 10.1053/j.jvca.2019.03.018. Epub 2019 Mar 14.

Authors

Vi Vu¹, Karen May-Newman²

Affiliations

¹ Bioengineering Program, Dept. of Mechanical Engineering, San Diego State University, San Diego, CA.
² Bioengineering Program, Dept. of Mechanical Engineering, San Diego State University, San Diego, CA. Electronic address: kmaynewm@sdsu.edu.

PMID: 31060942
DOI: 10.1053/j.jvca.2019.03.018

Abstract

The orientation and design of bileaflet valve prosthesis in the mitral position affects the intraventricular blood flow and exposure to shear. The combination of the anatomic orientation and a small gap size of the St. Jude Medical valve produces an increase in shear exposure and blood residence time, which both predispose the formation of thrombus in the high shear gaps of the valve hinges.

Keywords: bileaflet; flow; shear; thrombus.

Publication types

Editorial
Comment

MeSH terms

Heart Valve Prosthesis*
Humans
Mitral Valve
Prosthesis Design
Shock, Cardiogenic
Thrombosis*