Abstract
In eukaryotes, divergent transcription is a major source of noncoding RNAs. Recent studies have uncovered that in yeast, the transcription factor Rap1 restricts transcription in the divergent direction and thereby controls promoter directionality. Here, we summarize these findings, propose regulatory principles, and discuss the implications for eukaryotic gene regulation.
Keywords:
Rap1; directionality; divergent; noncoding RNA; promoter; repression; steric hindrance; transcription factor; yeast.
Publication types
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Promoter Regions, Genetic / genetics*
-
Saccharomyces cerevisiae / genetics*
-
Saccharomyces cerevisiae / metabolism
-
Saccharomyces cerevisiae Proteins / metabolism*
-
Shelterin Complex
-
Telomere-Binding Proteins / metabolism*
-
Transcription Factors / metabolism*
-
Transcription, Genetic / genetics*
Substances
-
RAP1 protein, S cerevisiae
-
Saccharomyces cerevisiae Proteins
-
Shelterin Complex
-
Telomere-Binding Proteins
-
Transcription Factors