An insight into chiral monolithic stationary phases for enantioselective high-performance liquid chromatography applications

Ali Fouad; Diana Ibrahim; Frady G Adly; Ashraf Ghanem

doi:10.1002/jssc.201900159

An insight into chiral monolithic stationary phases for enantioselective high-performance liquid chromatography applications

J Sep Sci. 2019 Jul;42(14):2303-2340. doi: 10.1002/jssc.201900159. Epub 2019 May 22.

Authors

Ali Fouad^{1

2}, Diana Ibrahim¹, Frady G Adly¹, Ashraf Ghanem¹

Affiliations

¹ Chirality Program, School of Science, Faculty of Science and Technology, University of Canberra, ACT, Australia.
² Pharmaceutical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt.

PMID: 31050176
DOI: 10.1002/jssc.201900159

Abstract

In this review, three main classes of chiral monolithic stationary phases, namely silica-, organic polymer-, and hybrid-based monolithic stationary phases, are covered. Their preparations, applications, and advantages compared with the conventional-packed and open-tubular capillary columns are discussed. A detailed description of the different types and techniques used for the introduction of chiral selectors into the monolithic matrices such as immobilization, functionalization, coating, encapsulation, and bonding. Special emphasis is given to the recent developments of chiral selectors in HPLC monolithic stationary phases during the past 18 years.

Keywords: HPLC; chirality; enantioslective separation; monoliths.

Publication types

Review

Grants and funding

Egyptian Cultural Affairs and the University of Canberra