Intelligent polymer-MnO2 nanoparticles for dual-activatable photoacoustic and magnetic resonance bimodal imaging in living mice

Xiaoming Hu; Chen Zhan; Yufu Tang; Feng Lu; Yuanyuan Li; Feng Pei; Xiaomei Lu; Yu Ji; Jie Li; Wenjun Wang; Quli Fan; Wei Huang

doi:10.1039/c9cc02148e

Intelligent polymer-MnO₂ nanoparticles for dual-activatable photoacoustic and magnetic resonance bimodal imaging in living mice

Chem Commun (Camb). 2019 May 28;55(43):6006-6009. doi: 10.1039/c9cc02148e. Epub 2019 May 3.

Authors

Xiaoming Hu¹, Chen Zhan¹, Yufu Tang¹, Feng Lu¹, Yuanyuan Li¹, Feng Pei², Xiaomei Lu², Yu Ji¹, Jie Li¹, Wenjun Wang³, Quli Fan¹, Wei Huang⁴

Affiliations

¹ Key Laboratory for Organic Electronics and Information Displays (KLOEID) & Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts & Telecommunications, 9 Wenyuan Road, Nanjing 210023, China. iamqlfan@njupt.edu.cn.
² Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing Tech University (NanjingTech), 30 South Puzhu Road, Nanjing 211816, China.
³ Key Lab of Optical Communication Science and Technology of Shandong Province & School of Physics Science and Information Engineering, Liaocheng University, Liaocheng 252059, China.
⁴ Key Laboratory for Organic Electronics and Information Displays (KLOEID) & Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts & Telecommunications, 9 Wenyuan Road, Nanjing 210023, China. iamqlfan@njupt.edu.cn and Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing Tech University (NanjingTech), 30 South Puzhu Road, Nanjing 211816, China and Shaanxi Institute of Flexible Electronics (SIFE), Northwestern Polytechnical University (NPU), Xi'an 710072, China.

PMID: 31049505
DOI: 10.1039/c9cc02148e

Abstract

Herein, we report a dual-activatable MRI/PAI strategy for bimodal tumor imaging using an intelligent platform based on degradable MnO₂ and a near-infrared absorptive polymer conjugated with BODIPY molecules. We believe the smart platform could promote the advance of numerous dual-activatable bimodal imaging techniques for biological applications.

MeSH terms

Animals
Boron Compounds / chemistry
Magnetic Resonance Imaging / methods*
Manganese Compounds / chemistry*
Mice
Neoplasms, Experimental / metabolism
Oxides / chemistry*
Photoacoustic Techniques / methods*
Polymers / chemistry*

Substances

4,4-difluoro-4-bora-3a,4a-diaza-s-indacene
Boron Compounds
Manganese Compounds
Oxides
Polymers
manganese oxide