Risk Factors Associated with Retinal Lesions Resulting from Widespread Systemic Infection

Yuki Nagasako; Keiji Inagaki; Satoshi Serizawa; Masafumi Hamada; Nariaki Echizen; Osamu Takahashi; Gautam A Deshpande; Kishiko Ohkoshi

doi:10.1016/j.oret.2016.12.011

Risk Factors Associated with Retinal Lesions Resulting from Widespread Systemic Infection

Ophthalmol Retina. 2017 Jul-Aug;1(4):333-338. doi: 10.1016/j.oret.2016.12.011. Epub 2017 Mar 6.

Authors

Yuki Nagasako¹, Keiji Inagaki², Satoshi Serizawa³, Masafumi Hamada³, Nariaki Echizen³, Osamu Takahashi³, Gautam A Deshpande⁴, Kishiko Ohkoshi²

Affiliations

¹ Department of Ophthalmology, St. Luke's International Hospital, Tokyo, Japan; Department of Neurology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan. Electronic address: nagasakotky@gmail.com.
² Department of Ophthalmology, St. Luke's International Hospital, Tokyo, Japan; St. Luke's International University, Tokyo, Japan.
³ Department of Ophthalmology, St. Luke's International Hospital, Tokyo, Japan.
⁴ Center for Clinical Epidemiology, St. Luke's International University, Tokyo, Japan.

PMID: 31047520
DOI: 10.1016/j.oret.2016.12.011

Abstract

Purpose: To clarify the prevalence, microbiologic features, and risk factors of endogenous intraocular infections in patients with positive fungal or bacterial blood culture results.

Design: Retrospective case series.

Participants: Inpatients (n = 433) with positive blood culture results who underwent an ophthalmology consultation between January 2006 and September 2012 in Japan.

Methods: We retrospectively reviewed the ophthalmology consultations of 433 inpatients with positive blood culture results. Clinical features of patients with confirmed chorioretinitis or endophthalmitis were analyzed through descriptive statistical methods and univariate and multivariate models.

Main outcome measures: Correlation of clinical features with retinal lesions of disseminated bacteremia or fungemia.

Results: Among 433 inpatients with positive blood culture results, 116 (26.8%) were unresponsive and 27 (6.2%) had subjective ocular symptoms. Eighty-four (19.4%) had candidemia, including 16 (3.7%) with retinal lesions. Additionally, 34 patients (7.8%) had chorioretinitis or endophthalmitis in 1 eye (17 patients [3.9%]) or both eyes (17 eyes [3.9%]; 51 eyes total). Of these 34 patients, 20 (58.8%) and 17 (50%) had systemic bacterial and fungal infections, respectively (both infections were noted in 3 patients [8.8%]). Staphylococcus aureus was the most common bacteria. Candida albicans was the most common fungus, followed by Candida glabrata. Catheter-related bloodstream infections were the most common source of infection among the 34 patients with chorioretinitis or endophthalmitis, followed by infective endocarditis, urinary tract infection, and soft-tissue and bone disease. Among the 114 bacteremic patients who underwent an ophthalmology consultation because of suspicion of infective endocarditis, only 16 (14%) had infective endocarditis, of whom only 1 (0.88%) had retinal lesions. Nineteen of 34 patients (55.9%) with retinal lesions survived sepsis. Among them, only 1 patient (5.3%) with bacteremia lost significant vision (no light perception), and the remaining 18 patients (94.7%) regained vision. No patient with candidemia had vision loss. Multivariate analysis revealed that candidemia, infective endocarditis, broad-spectrum antibiotic use, and eye symptoms were independent predictors of retinal lesions (all P < 0.05).

Conclusions: An ophthalmology consultation may be useful for patients with candidemia, infective endocarditis, broad-spectrum antibiotic use, or ocular symptoms. However, routine ophthalmologic evaluation may be less efficient for bacteremic patients without definitive infective endocarditis lacking other risk factors.