A novel Ca2+-signal transduction inhibitor, kujigamberol C, isolated from Kuji amber

Biosci Biotechnol Biochem. 2019 Sep;83(9):1630-1634. doi: 10.1080/09168451.2019.1611410. Epub 2019 May 2.

Abstract

A novel labdane type diterpenoid, 15-nor-8-labden-13-ol, named kujigamberol C, was isolated from Kuji amber using a modified isolation method to increase the yield of biologically active compounds. The structure was determined using HREIMS, 1D and 2D NMR. Kujigamberol C showed growth-restoring activity against mutant yeast via Ca2+-signal transduction.

Keywords: 15-nor-8-labden-13-ol; Kuji amber; kujigamberol C.

MeSH terms

  • Amber / chemistry*
  • Animals
  • Calcium Signaling / drug effects*
  • Cell Line
  • Diterpenes / isolation & purification
  • Diterpenes / pharmacology*
  • Magnetic Resonance Spectroscopy / methods
  • Rats
  • Spectrometry, Mass, Electrospray Ionization / methods

Substances

  • 15,20-dinor-5,7,9-labdatriene-18-ol
  • Amber
  • Diterpenes