Evaluation of the effects of silver nanoparticles on Danio rerio cornea: Morphological and ultrastructural analysis

Microsc Res Tech. 2019 Aug;82(8):1297-1301. doi: 10.1002/jemt.23280. Epub 2019 May 2.

Abstract

Although in recent years there has been intensification in the use of nanoparticles (NPs) for the production of many commercial products, few studies have been carried out to assess the risks associated with its use. Among the most used NPs, silver nanoparticles (AgNPs) have a preponderant position as they have various applications. In this study, 40 adult zebrafish were exposed to increasing concentrations of AgNPs (8, 45, and 70 μg/L) for 30 days to evaluate the effects on eyes after chronic exposure to AgNPs with an average diameter of 50 nm. From the morphological and ultrastructural analysis performed, no alteration or lesions of the corneal epithelium were detected.

Keywords: eyes; morphostructure; nanocomposite; zebrafish.

Publication types

  • Evaluation Study

MeSH terms

  • Animals
  • Cornea / drug effects*
  • Cornea / ultrastructure*
  • Epithelium, Corneal / drug effects
  • Metal Nanoparticles / chemistry*
  • Metal Nanoparticles / toxicity
  • Silver / pharmacology*
  • Silver / toxicity
  • Water Pollutants, Chemical / pharmacology
  • Water Pollutants, Chemical / toxicity
  • Zebrafish / anatomy & histology*

Substances

  • Water Pollutants, Chemical
  • Silver