Abstract
Urolithin A (Uro-A) is an anti-inflammatory and cancer chemopreventive metabolite produced by the gut microbiota from the polyphenol ellagic acid. However, in vivo conjugation of Uro-A to Uro-A glucuronide (Uro-A glur) dramatically hampers its activity. We describe here for the first time the tissue deconjugation of Uro-A glur to Uro-A after lipopolysaccharide (LPS)-induced inflammation, which could explain the systemic in vivo activity of free Uro-A in microenvironments subjected to inflammatory stimuli.
MeSH terms
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Animals
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Coumarins / administration & dosage
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Coumarins / chemistry
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Coumarins / pharmacokinetics*
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Ellagic Acid / metabolism
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Gastrointestinal Microbiome
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Gastrointestinal Tract / microbiology
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Glucuronides / administration & dosage
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Glucuronides / chemistry
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Glucuronides / pharmacokinetics*
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Humans
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Inflammation / drug therapy*
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Inflammation / metabolism
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Inflammation / microbiology
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Male
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Rats
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Rats, Sprague-Dawley
Substances
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3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one glucuronide
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Coumarins
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Glucuronides
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3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one
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Ellagic Acid