BRCA Mutation Carriers: Breast and Ovarian Cancer Screening Guidelines and Imaging Considerations

Radiology. 2019 Jun;291(3):554-569. doi: 10.1148/radiol.2019181814. Epub 2019 Apr 30.

Abstract

Patients who carry the BRCA1 and BRCA2 gene mutations have an underlying genetic predisposition for breast and ovarian cancers. These deleterious genetic mutations are the most common genes implicated in hereditary breast and ovarian cancers. This monograph summarizes the evidence behind current screening recommendations, reviews imaging protocols specific to this patient population, and illustrates some of the imaging nuances of breast and ovarian cancers in this clinical setting.

Publication types

  • Review

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • BRCA1 Protein / genetics*
  • BRCA2 Protein / genetics*
  • Breast Neoplasms* / diagnostic imaging
  • Breast Neoplasms* / genetics
  • Early Detection of Cancer / methods*
  • Female
  • Humans
  • Middle Aged
  • Ovarian Neoplasms* / diagnostic imaging
  • Ovarian Neoplasms* / genetics
  • Practice Guidelines as Topic
  • Risk Assessment
  • Young Adult

Substances

  • BRCA1 Protein
  • BRCA1 protein, human
  • BRCA2 Protein