Comparison of different methods for the extraction of cannabinoids from cannabis

Nat Prod Res. 2020 Oct;34(20):2952-2958. doi: 10.1080/14786419.2019.1601194. Epub 2019 Apr 29.

Abstract

Cannabis oils, namely concentrated cannabis extracts, are getting plenty of attention because of their therapeutic potential for treatment of patients with cancer, HIV, multiple sclerosis and several other pathologies. Here we propose the use of ultrasound-assisted extraction (UAE) and microwave-assisted extraction (MAE) as alternative methods to the current protocols followed by pharmacists, the only authorized to manipulate standardized Cannabis. A third method, consisting of the use of Tween 20 as surfactant, was considered. Our best extraction methodology for commercial hemp extraction was applied to medicinal cannabis. Here we report the results obtained for 'Eletta campana', 'Carmagnola selezionata', Bediol®, FM2® and Bedrocan®.

Keywords: Cannabis extraction; industrial hemp; medicinal cannabis; microwave-assisted extraction; ultrasound-assisted extraction.

Publication types

  • Comparative Study

MeSH terms

  • Cannabinoids / chemistry
  • Cannabinoids / isolation & purification*
  • Cannabis / chemistry*
  • Chemical Fractionation / methods*
  • Microwaves
  • Molecular Structure
  • Plant Extracts / chemistry
  • Polysorbates / chemistry
  • Surface-Active Agents / chemistry
  • Ultrasonics

Substances

  • Cannabinoids
  • Plant Extracts
  • Polysorbates
  • Surface-Active Agents