Effect of Inflammation on the Process of Stroke Rehabilitation and Poststroke Depression

Meidan Fang; Lili Zhong; Xin Jin; Ranji Cui; Wei Yang; Shuohui Gao; Jing Lv; Bingjin Li; Tongjun Liu

doi:10.3389/fpsyt.2019.00184

Effect of Inflammation on the Process of Stroke Rehabilitation and Poststroke Depression

Front Psychiatry. 2019 Apr 11:10:184. doi: 10.3389/fpsyt.2019.00184. eCollection 2019.

Authors

Meidan Fang¹, Lili Zhong², Xin Jin³, Ranji Cui², Wei Yang², Shuohui Gao⁴, Jing Lv⁵, Bingjin Li², Tongjun Liu¹

Affiliations

¹ Department of General Surgery, Second Hospital of Jilin University, Changchun, China.
² Jilin Provincial Key Laboratory on Molecular and Chemical Genetic, Second Hospital of Jilin University, Changchun, China.
³ Department of Oncology and Hematology, Second Hospital of Jilin University, Changchun, China.
⁴ Department of Gastrointestinal Colorectal Surgery, China-Japan Union Hospital of Jilin University, Changchun, China.
⁵ Chang Chun University of Chinese Medicine, Changchun, China.

Abstract

A considerable body of evidence has shown that inflammation plays an important role in the process of stroke rehabilitation and development of poststroke depression (PSD). However, the specific molecular and cellular mechanisms involved remain unclear. In this review, we summarize how neuroinflammation affects stroke rehabilitation and PSD. We mainly focus on the immune/inflammatory response, involving astrocytes, microglia, monocyte-derived macrophages, cytokines (tumor necrosis factor alpha, interleukin 1), and microRNAs (microRNA-124, microRNA 133b). This review provides new insights into the effect of inflammation on the process of stroke rehabilitation and PSD and potentially offer new therapeutic targets of stroke and PSD.

Keywords: immune/inflammation; pharmacotherapy; poststroke depression; rehabilitation; stroke.

Publication types

Review