Drugs in renal disease and pregnancy

Asif Sarwar

doi:10.1016/j.bpobgyn.2019.03.006

Drugs in renal disease and pregnancy

Best Pract Res Clin Obstet Gynaecol. 2019 May:57:106-119. doi: 10.1016/j.bpobgyn.2019.03.006. Epub 2019 Apr 3.

Author

Asif Sarwar¹

Affiliation

¹ Advanced Clinical Pharmacist - Electronic Prescribing, Pharmacy Department, University Hospitals Birmingham NHS Foundation Trust, Queen Elizabeth Hospital, Birmingham, B15 2TH, England, United Kingdom. Electronic address: asif.sarwar@uhb.nhs.uk.

PMID: 31031053
DOI: 10.1016/j.bpobgyn.2019.03.006

Abstract

This review aims to summarise historic and the latest evidence of commonly used drugs in pregnant women with chronic kidney disease (CKD). Data regarding safety of drugs in breastfeeding are also described. Practical recommendations are made on the use of newer agents that have limited information of use in pregnant women with CKD. Pharmacokinetic and dynamic issues are outlined, and general principles for prescribing drugs in pregnant women with CKD are listed. Resources to investigate drug safety are presented.

Keywords: Chronic kidney disease; Foetotoxicity; Lactation; Pregnancy safety; Teratogenicity.

Publication types

Review

MeSH terms

Drug-Related Side Effects and Adverse Reactions
Female
Humans
Pharmaceutical Preparations*
Pharmacokinetics
Pregnancy
Pregnancy Complications / physiopathology*
Renal Insufficiency, Chronic / physiopathology*

Substances

Pharmaceutical Preparations