Adjuvant haploidentical virus-specific T lymphocytes for treatment of disseminated adenovirus infection in a premature infant

J Allergy Clin Immunol. 2019 Aug;144(2):594-597.e4. doi: 10.1016/j.jaci.2019.04.006. Epub 2019 Apr 23.

Abstract

We report the first therapeutic infusion of haploidentical virus-specific T lymphocytes (VSTs) to treat maternally-transmitted, disseminated adenovirus infection in a premature infant. Infusion of maternal VSTs, isolated using interferon-gamma capture, associated with clinical improvement and viral clearance.

Publication types

  • Case Reports
  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenoviridae Infections* / immunology
  • Adenoviridae Infections* / pathology
  • Adenoviridae Infections* / therapy
  • Adoptive Transfer*
  • Female
  • Humans
  • Infant, Newborn
  • Infant, Newborn, Diseases* / immunology
  • Infant, Newborn, Diseases* / pathology
  • Infant, Newborn, Diseases* / therapy
  • Infant, Premature
  • T-Lymphocytes* / immunology
  • T-Lymphocytes* / transplantation