Characterization of a cryptic IGH/CCND1 rearrangement in a case of mantle cell lymphoma with negative CCND1 FISH studies

Blood Adv. 2019 Apr 23;3(8):1298-1302. doi: 10.1182/bloodadvances.2019031450.

Affiliations

¹ Division of Laboratory Genetics and Genomics, Department of Laboratory Medicine and Pathology.
² Division of Hematopathology, Department of Laboratory Medicine and Pathology.
³ Center for Individualized Medicine-Biomarker Discovery, and.
⁴ Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN.

Abstract

This article characterizes a cryptic IGH/CCND1 rearrangement in MCL by NGS.
Mate-pair sequencing can help in accurately diagnosing MCL in cases of cyclin-D1–positive B-cell lymphoma with negative CCND1 FISH studies.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Female
Humans
In Situ Hybridization, Fluorescence*
Lymphoma, Mantle-Cell* / drug therapy
Lymphoma, Mantle-Cell* / genetics
Lymphoma, Mantle-Cell* / metabolism
Lymphoma, Mantle-Cell* / pathology
Oncogene Proteins, Fusion* / genetics
Oncogene Proteins, Fusion* / metabolism
Translocation, Genetic*

Substances

IGH-CCND1 fusion protein, human
Oncogene Proteins, Fusion