3D Bioprinting in Skeletal Muscle Tissue Engineering

Serge Ostrovidov; Sahar Salehi; Marco Costantini; Kasinan Suthiwanich; Majid Ebrahimi; Ramin Banan Sadeghian; Toshinori Fujie; Xuetao Shi; Stefano Cannata; Cesare Gargioli; Ali Tamayol; Mehmet Remzi Dokmeci; Gorka Orive; Wojciech Swieszkowski; Ali Khademhosseini

doi:10.1002/smll.201805530

3D Bioprinting in Skeletal Muscle Tissue Engineering

Small. 2019 Jun;15(24):e1805530. doi: 10.1002/smll.201805530. Epub 2019 Apr 23.

Authors

Serge Ostrovidov¹, Sahar Salehi², Marco Costantini³, Kasinan Suthiwanich^{1

4}, Majid Ebrahimi⁵, Ramin Banan Sadeghian⁶, Toshinori Fujie^{7

8}, Xuetao Shi⁹, Stefano Cannata¹⁰, Cesare Gargioli¹⁰, Ali Tamayol¹¹, Mehmet Remzi Dokmeci¹, Gorka Orive^{12

13

14}, Wojciech Swieszkowski¹⁵, Ali Khademhosseini^{1

16

17

18

19}

Affiliations

¹ Center for Minimally Invasive Therapeutics (C-MIT), Department of Radiological Sciences, University of California, Los Angeles, CA, 90095, USA.
² Department of Biomaterials, Faculty of Engineering Science, University of Bayreuth, Bayreuth, 95440, Germany.
³ Institute of Physical Chemistry - Polish Academy of Sciences, 01-224, Warsaw, Poland.
⁴ Department of Materials Science and Engineering, Tokyo Institute of Technology, Yokohama, 226-8503, Japan.
⁵ Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, M5S3G9, Canada.
⁶ Graduate School of Engineering, Department of Micro Engineering, Kyoto University, Kyoto, 615-8540, Japan.
⁷ School of Life Science and Technology, Tokyo Institute of Technology, B-50, 4259 Nagatsuta -cho, Midori-ku, Yokohama, 226-8501, Japan.
⁸ PRESTO, Japan Science and Technology Agency, 4-1-8, Honcho, Kawaguchi-shi, Saitama, 332-0012, Japan.
⁹ National Engineering Research Centre for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510006, P. R. China.
¹⁰ Department of Biology, Tor Vergata Rome University, Rome, 00133, Italy.
¹¹ Department of Mechanical and Materials Engineering, University of Nebraska, Lincoln, NE, 68588, USA.
¹² NanoBioCel Group, Laboratory of Pharmaceutics, School of Pharmacy, University of the Basque Country UPV/EHU, Paseo de la Universidad 7, 01006, Vitoria-Gasteiz, Spain.
¹³ Biomedical Research Networking Centre in Bioengineering, Biomaterials, and Nanomedicine (CIBER-BBN), Vitoria-Gasteiz, 01007, Spain.
¹⁴ University Institute for Regenerative Medicine and Oral Implantology - UIRMI (UPV/EHU-Fundación Eduardo Anitua), Vitoria, 01007, Spain.
¹⁵ Faculty of Materials Science and Engineering, Warsaw University of Technology, 02-507, Warsaw, Poland.
¹⁶ California NanoSystems Institute (CNSI), University of California, Los Angeles, CA, 90095, USA.
¹⁷ Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, CA, 90095, USA.
¹⁸ Department of Bioengineering, University of California, Los Angeles, CA, 90095, USA.
¹⁹ Jonsson Comprehensive Cancer Centre, University of California, Los Angeles, CA, 90095, USA.

Abstract

Skeletal muscle tissue engineering (SMTE) aims at repairing defective skeletal muscles. Until now, numerous developments are made in SMTE; however, it is still challenging to recapitulate the complexity of muscles with current methods of fabrication. Here, after a brief description of the anatomy of skeletal muscle and a short state-of-the-art on developments made in SMTE with "conventional methods," the use of 3D bioprinting as a new tool for SMTE is in focus. The current bioprinting methods are discussed, and an overview of the bioink formulations and properties used in 3D bioprinting is provided. Finally, different advances made in SMTE by 3D bioprinting are highlighted, and future needs and a short perspective are provided.

Keywords: 3D printing; bioinks; bioprinting; hydrogels; skeletal muscle; tissue engineering.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Bioprinting / instrumentation
Bioprinting / methods*
Cell Culture Techniques / instrumentation
Cell Culture Techniques / methods
Cells, Cultured
Humans
Muscle, Skeletal / cytology*
Muscle, Skeletal / physiology*
Printing, Three-Dimensional*
Regenerative Medicine / instrumentation
Regenerative Medicine / methods
Tissue Engineering* / instrumentation
Tissue Engineering* / methods
Tissue Scaffolds* / chemistry

Abstract

Publication types

MeSH terms

Grants and funding