One new xanthenone from the marine-derived fungus Aspergillus versicolor MF160003

Zhijun Song; Jieyu Gao; Jiansen Hu; Hongtao He; Pei Huang; Lixin Zhang; Fuhang Song

doi:10.1080/14786419.2019.1597355

One new xanthenone from the marine-derived fungus Aspergillus versicolor MF160003

Nat Prod Res. 2020 Oct;34(20):2907-2912. doi: 10.1080/14786419.2019.1597355. Epub 2019 Apr 22.

Authors

Zhijun Song^{1

2}, Jieyu Gao^{1

3}, Jiansen Hu^{1

2}, Hongtao He^{1

2}, Pei Huang^{1

4}, Lixin Zhang⁵, Fuhang Song¹

Affiliations

¹ Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
² University of Chinese Academy of Sciences, Beijing, China.
³ School of Food and Biological Engineering, Hefei University of Technology, Hefei, China.
⁴ Department of Pediatrics, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
⁵ State Key Laboratory of Bioreactor Engineering, East China University of Science of Technology, Shanghai, China.

PMID: 31009246
DOI: 10.1080/14786419.2019.1597355

Abstract

A new xanthenone derivative, 3-hydroxy pinselin (1), together with five known analogues (2-6) were isolated from the marine-derived fungus Aspergillus versicolor MF160003. Their structures were identified by extensive 1D- and 2D-NMR, and high-resolution mass spectrometry data. Compounds 5 and 6 showed moderate bioactivities against BCG with MIC values of 40 and 20 μg/mL, respectively.

Keywords: Aspergillus versicolor; Marine-derived fungus; anti-BCG; xanthenone.

MeSH terms

Aspergillus / chemistry*
Magnetic Resonance Spectroscopy
Mass Spectrometry
Microbial Sensitivity Tests
Molecular Structure
Mycobacterium bovis / drug effects
Xanthenes / chemistry
Xanthenes / isolation & purification*
Xanthenes / pharmacology

Substances

Xanthenes