Production of 191Pt from an iridium target by vertical beam irradiation and simultaneous alkali fusion

Honoka Obata; Katsuyuki Minegishi; Kotaro Nagatsu; Ming-Rong Zhang; Atsushi Shinohara

doi:10.1016/j.apradiso.2019.04.007

Production of ¹⁹¹Pt from an iridium target by vertical beam irradiation and simultaneous alkali fusion

Appl Radiat Isot. 2019 Jul:149:31-37. doi: 10.1016/j.apradiso.2019.04.007. Epub 2019 Apr 11.

Authors

Honoka Obata¹, Katsuyuki Minegishi², Kotaro Nagatsu³, Ming-Rong Zhang², Atsushi Shinohara⁴

Affiliations

¹ Graduate School of Science, Osaka University, 1-1 Machikaneyama, Toyonaka, Osaka, 560-0043, Japan; Department of Advanced Nuclear Medicine Sciences, National Institute of Radiological Sciences (NIRS), National Institutes for Quantum and Radiological Science and Technology (QST), 4-9-1 Anagawa, Inage, Chiba, 263-8555, Japan.
² Department of Advanced Nuclear Medicine Sciences, National Institute of Radiological Sciences (NIRS), National Institutes for Quantum and Radiological Science and Technology (QST), 4-9-1 Anagawa, Inage, Chiba, 263-8555, Japan.
³ Department of Advanced Nuclear Medicine Sciences, National Institute of Radiological Sciences (NIRS), National Institutes for Quantum and Radiological Science and Technology (QST), 4-9-1 Anagawa, Inage, Chiba, 263-8555, Japan. Electronic address: nagatsu.kotaro@qst.go.jp.
⁴ Graduate School of Science, Osaka University, 1-1 Machikaneyama, Toyonaka, Osaka, 560-0043, Japan.

PMID: 31005643
DOI: 10.1016/j.apradiso.2019.04.007

Abstract

We have developed a new method for producing ¹⁹¹Pt from an iridium target. Alkali fusion of iridium was successfully performed using a vertical beam irradiation method and a mixed target of Ir and Na₂O₂, which resulted in easy dissolution of the irradiated iridium target. A trace amount of Pt^ⅣCl₆^2- was isolated from bulk Ir^ⅣCl₆^2- by solvent extraction and anion exchange chromatography. The production yield of ¹⁹¹Pt was 7.1 ± 0.4 (MBq/μA h, EOB) by proton irradiation at 30 MeV. The radioplatinum product (n.c.a.) was prepared at a radiochemical purity of 97% for Pt^ⅣCl₆^2-, and 95% for Pt^ⅡCl₄^2-, respectively.

Keywords: Alkali fusion; Anion exchange chromatography; Iridium target; Platinum-191; Radiotheranostics; Solvent extraction; Vertical beam irradiation.