Safety Assessment of Immune-Mediated Adverse Reactions to Novel Food Proteins

Antonio Fernandez; E N Clare Mills; Frits Koning; F Javier Moreno

doi:10.1016/j.tibtech.2019.03.010

Safety Assessment of Immune-Mediated Adverse Reactions to Novel Food Proteins

Trends Biotechnol. 2019 Aug;37(8):796-800. doi: 10.1016/j.tibtech.2019.03.010. Epub 2019 Apr 17.

Authors

Antonio Fernandez¹, E N Clare Mills², Frits Koning³, F Javier Moreno⁴

Affiliations

¹ European Food Safety Authority (EFSA), via Carlo Magno 1A, 43021 Parma, Italy. Electronic address: antonio.fernandezdumont@efsa.europa.eu.
² Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Manchester Institute of Biotechnology, Manchester Academic Health Sciences Centre, The University of Manchester, Manchester, UK.
³ Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, Leiden 2333, ZA, The Netherlands.
⁴ Instituto de Investigación en Ciencias de la Alimentación, CIAL (CSIC-UAM), C/ Nicolás Cabrera, 9, Campus de la Universidad Autónoma de Madrid, 28049 Madrid, Spain.

PMID: 31005332
DOI: 10.1016/j.tibtech.2019.03.010

Abstract

Current international guidelines for the risk assessment of biotechnology-derived foods date back to 2003. We present new strategies and directions for assessing immune adverse reactions to novel food proteins. Understanding genetic factors involved in food allergy and the role of the gastrointestinal tract will streamline risk assessment strategies.

Keywords: HLA genotype; celiac disease; immune mediated; in vitro digestion models; novel proteins; risk assessment.

Publication types

Review

MeSH terms

Allergens / immunology*
Food / adverse effects*
Food Analysis / methods*
Food Hypersensitivity / etiology*
Food Hypersensitivity / prevention & control*
Food Safety / methods*
Humans
Proteins / immunology*

Substances

Allergens
Proteins