Abstract
Vagiallene (1), a rearranged C15 acetogenin with a molecular formula and a carbon skeleton unprecedented in natural products, was isolated as a trace constituent from the organic extract of the red alga Laurencia obtusa from Lefkada island. The planar structure and the relative configuration of 1 were established on the basis of extensive analysis of its spectroscopic data, while its absolute configuration was determined by comparison of its experimental and quantum-mechanically predicted electronic circular dichroism spectra.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetogenins / chemistry*
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Acetogenins / isolation & purification
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Acetogenins / pharmacology
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology
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Cell Line, Tumor
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Cell Survival / drug effects
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Humans
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Isomerism
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Laurencia / chemistry*
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Molecular Conformation
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Molecular Dynamics Simulation
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Molecular Structure
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Plant Extracts / chemistry*
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Plant Extracts / isolation & purification
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Quantum Theory
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Thermodynamics
Substances
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Acetogenins
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Antineoplastic Agents
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Plant Extracts