Cobalt(II) complexes with the non-steroidal anti-inflammatory drug diclofenac and nitrogen-donor ligands

Spyros Perontsis; Alexandra Dimitriou; Panagiota Fotiadou; Antonios G Hatzidimitriou; Athanasios N Papadopoulos; George Psomas

doi:10.1016/j.jinorgbio.2019.04.002

Cobalt(II) complexes with the non-steroidal anti-inflammatory drug diclofenac and nitrogen-donor ligands

J Inorg Biochem. 2019 Jul:196:110688. doi: 10.1016/j.jinorgbio.2019.04.002. Epub 2019 Apr 5.

Authors

Spyros Perontsis¹, Alexandra Dimitriou¹, Panagiota Fotiadou¹, Antonios G Hatzidimitriou¹, Athanasios N Papadopoulos², George Psomas³

Affiliations

¹ Laboratory of Inorganic Chemistry, Faculty of Chemistry, Aristotle University of Thessaloniki, GR-54124 Thessaloniki, Greece.
² Department of Nutrition and Dietetics, Faculty of Food Technology and Nutrition, Alexandrion Technological Educational Institution, Sindos, Thessaloniki, Greece.
³ Laboratory of Inorganic Chemistry, Faculty of Chemistry, Aristotle University of Thessaloniki, GR-54124 Thessaloniki, Greece. Electronic address: gepsomas@chem.auth.gr.

PMID: 30999222
DOI: 10.1016/j.jinorgbio.2019.04.002

Abstract

The interaction of the non-steroidal anti-inflammatory drug sodium diclofenac with CoCl₂ in the absence or presence of the nitrogen-donor ligands 2,2'-bipyridine, 1,10-phenanthroline, 2,2'-bipyridylamine, pyridine or imidazole resulted in the formation of six mononuclear Co(II) complexes. The complexes were characterized by diverse physicochemical and spectroscopic techniques and single-crystal X-ray crystallography revealing a monodentate or a bidentate chelating binding mode of the diclofenac ligands. The scavenging activity of the complexes was evaluated in vitro against the free radicals of 1,1-diphenyl-2-picrylhydrazyl, 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and hydroxyl; the complexes present significant scavenging activity of ABTS and hydroxyl radicals. The interaction of the complexes with calf-thymus (CT) DNA and bovine serum albumin (BSA) was also investigated; the complexes can bind tightly to CT DNA via intercalation and can bind to BSA tightly and reversibly.

Keywords: Antioxidant activity; Cobalt(II) complexes; Diclofenac; Interaction with DNA; Interaction with albumins.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Inflammatory Agents, Non-Steroidal / chemistry*
Cobalt / chemistry*
Coordination Complexes / chemistry
Diclofenac / chemistry*
Intercalating Agents / chemistry
Ligands*
Mefenamic Acid / chemistry
Molecular Structure
Nitrogen / chemistry*

Substances

Anti-Inflammatory Agents, Non-Steroidal
Coordination Complexes
Intercalating Agents
Ligands
Diclofenac
Mefenamic Acid
Cobalt
Nitrogen