Measuring accurate translational self-diffusion coefficients (Dt ) by NMR techniques with modern spectrometers has become rather routine. In contrast, the derivation of reliable molecular information therefrom still remains a nontrivial task. In this paper, two established approaches to estimating molecular size in terms of hydrodynamic volume (VH ) or molecular weight (M) are compared. Ad hoc designed experiments allowed the critical aspects of their application to be explored by translating relatively complex theoretical principles into practical take-home messages. For instance, comparing the Dt values of three isosteric Cp2 MCl2 complexes (Cp=cyclopentadienyl, M=Ti, Zr, Hf), having significantly different molecular mass, provided an empirical demonstration that VH is the critical molecular property affecting Dt . This central concept served to clarify the assumptions behind the derivation of Dt =ƒ(M) power laws from the Stokes-Einstein equation. Some pitfalls in establishing log (Dt ) versus log (M) linear correlations for a set of species have been highlighted by further investigations of selected examples. The effectiveness of the Stokes-Einstein equation itself in describing the aggregation or polymerization of differently shaped species has been explored by comparing, for example, a ball-shaped silsesquioxane cage with its cigar-like dimeric form, or styrene with polystyrene macromolecules.
Keywords: Group IV elements; NMR spectroscopy; diffusion; hydrodynamic volume; molecular weight; semi-empirical calculations.
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