Abstract
Six new nardosinane-type sesquiterpenoids, clavukoellians A-F (1-6), together with one new neolemnane-type sesquiterpene, 4- O-deacetylparalemnolin D (7), were isolated from the marine soft coral Clavularia koellikeri. The structures of compounds 1-7 were elucidated by NMR spectroscopy, ECD analysis, and quantum chemical calculation methods. Compounds 1 and 7 demonstrated significant antiangiogenic activities in wound healing assays on HUVECs.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Angiogenesis Inhibitors / chemistry*
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Angiogenesis Inhibitors / pharmacology*
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Animals
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Anthozoa / chemistry*
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Cell Line, Tumor
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Cell Proliferation
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Drug Screening Assays, Antitumor
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Human Umbilical Vein Endothelial Cells / drug effects
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Humans
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Molecular Structure
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Neovascularization, Pathologic / prevention & control
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Nuclear Magnetic Resonance, Biomolecular
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Sesquiterpenes / chemistry*
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Sesquiterpenes / pharmacology*
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Wound Healing / drug effects
Substances
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Angiogenesis Inhibitors
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Sesquiterpenes