Inhibition of LSD1 by small molecule inhibitors stimulates fetal hemoglobin synthesis

Blood. 2019 May 30;133(22):2455-2459. doi: 10.1182/blood.2018892737. Epub 2019 Apr 16.
No abstract available

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anemia, Sickle Cell / drug therapy*
  • Anemia, Sickle Cell / metabolism
  • Anemia, Sickle Cell / pathology
  • Animals
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology*
  • Erythroid Cells / metabolism*
  • Erythroid Cells / pathology
  • Fetal Hemoglobin / biosynthesis*
  • Histone Demethylases / antagonists & inhibitors*
  • Histone Demethylases / metabolism
  • Humans
  • Induced Pluripotent Stem Cells / metabolism*
  • Induced Pluripotent Stem Cells / pathology
  • Mice

Substances

  • Enzyme Inhibitors
  • Fetal Hemoglobin
  • Histone Demethylases
  • KDM1A protein, human