Descemet Membrane Endothelial Keratoplasty Failure Associated with Innate Immune Activation

Zala Lužnik; Silke Oellerich; Karin Roesch; Jia Yin; Markus Zumbansen; Lars Franken; Gerrit R J Melles; Reza Dana

doi:10.1016/j.ophtha.2019.04.016

Descemet Membrane Endothelial Keratoplasty Failure Associated with Innate Immune Activation

Ophthalmology. 2019 Oct;126(10):1462-1464. doi: 10.1016/j.ophtha.2019.04.016. Epub 2019 Apr 12.

Authors

Zala Lužnik¹, Silke Oellerich², Karin Roesch³, Jia Yin¹, Markus Zumbansen³, Lars Franken³, Gerrit R J Melles⁴, Reza Dana⁵

Affiliations

¹ Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts.
² Netherlands Institute for Innovative Ocular Surgery, Rotterdam, The Netherlands.
³ AYOXXA Biosystems, Inc, Cologne, Germany.
⁴ Netherlands Institute for Innovative Ocular Surgery, Rotterdam, The Netherlands; Melles Cornea Clinic Rotterdam, Rotterdam, The Netherlands.
⁵ Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts. Electronic address: Reza_Dana@meei.harvard.edu.

Abstract

A retrospective case-control study found significantly increased levels of interleukin-5 and interleukin-8, critical cytokines of the innate immune system, in the aqueous humor of patients undergoing repeat DMEK for graft failure, compared to primary DMEK.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Aged
Aqueous Humor / metabolism
Corneal Diseases / immunology
Corneal Diseases / surgery*
Cytokines / metabolism
Descemet Membrane / surgery
Descemet Stripping Endothelial Keratoplasty*
Female
Humans
Immunity, Innate
Male
Middle Aged
Pilot Projects
Retrospective Studies
Treatment Failure

Substances

Cytokines

Abstract

Publication types

MeSH terms

Substances

Grants and funding