High antibacterial activity of chitosan - molybdenum disulfide nanocomposite

Wenbo Cao; Lin Yue; Zhouping Wang

doi:10.1016/j.carbpol.2019.03.085

High antibacterial activity of chitosan - molybdenum disulfide nanocomposite

Carbohydr Polym. 2019 Jul 1:215:226-234. doi: 10.1016/j.carbpol.2019.03.085. Epub 2019 Mar 26.

Authors

Wenbo Cao¹, Lin Yue², Zhouping Wang³

Affiliations

¹ State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, PR China; School of Food Science and Technology, Jiangnan University, Wuxi 214122, PR China.
² State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, PR China; School of Food Science and Technology, Jiangnan University, Wuxi 214122, PR China. Electronic address: yuelin@jiangnan.edu.cn.
³ State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, PR China; School of Food Science and Technology, Jiangnan University, Wuxi 214122, PR China. Electronic address: wangzp@jiangnan.edu.cn.

PMID: 30981349
DOI: 10.1016/j.carbpol.2019.03.085

Abstract

Bacterial infections have evolved as a life-threatening problem afflicting people due to the abuse of antibiotics and emergence of drug-resistant bacteria. Thus developing novel antibacterial materials is an urgent need. Herein, chitosan-MoS₂ (CS-MoS₂) nanocomposite was synthesized through thiol ligand functionalization and chemical modification to achieve more efficient bactericidal activity. CS-MoS₂ exhibited synergistic remarkable bactericidal capability against Gram-positive Staphylococcus aureus (S. aureus) and Gram-negative Escherichia coli (E.coli), where bacterial viabilities were significantly reduced. After treatment with 10 μg/mL of CS-MoS₂, 100% and 98.1% of S. aureus and E.coli cells were killed respectively. A mechanism study revealed that the positively charged CS-MoS₂ could interact with cell membrane, then cause damage to the membrane and cellular constituents by generation of reactive oxygen species (ROS) and glutathione (GSH) oxidation, finally inhibit bacterial growth. The CS-MoS₂ could be an attractive antibacterial agent with improved efficiency and provide more strategies for application of MoS₂.

Keywords: Antibacterial; Chitosan-MoS(2); Functionalization; Nanocomposite.

MeSH terms

Anti-Bacterial Agents / chemistry*
Anti-Bacterial Agents / pharmacology
Chitosan* / chemistry
Chitosan* / pharmacology
Disulfides* / chemistry
Disulfides* / pharmacology
Escherichia coli / drug effects*
Molybdenum* / chemistry
Molybdenum* / pharmacology
Nanocomposites / chemistry*
Staphylococcus aureus / drug effects*

Substances

Anti-Bacterial Agents
Disulfides
Molybdenum
Chitosan
molybdenum disulfide