Expanding the activity spectrum of antiviral agents

Aleksandr Ianevski; Petter I Andersen; Andres Merits; Magnar Bjørås; Denis Kainov

doi:10.1016/j.drudis.2019.04.006

Expanding the activity spectrum of antiviral agents

Drug Discov Today. 2019 May;24(5):1224-1228. doi: 10.1016/j.drudis.2019.04.006. Epub 2019 Apr 10.

Authors

Aleksandr Ianevski¹, Petter I Andersen¹, Andres Merits², Magnar Bjørås³, Denis Kainov⁴

Affiliations

¹ Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim 7028, Norway.
² Institute of Technology, University of Tartu, Tartu 50090, Estonia.
³ Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim 7028, Norway; Department of Microbiology, Oslo University Hospital and University of Oslo, Oslo 0027, Norway.
⁴ Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim 7028, Norway; Institute of Technology, University of Tartu, Tartu 50090, Estonia. Electronic address: denis.kainov@ntnu.no.

PMID: 30980905
DOI: 10.1016/j.drudis.2019.04.006

Abstract

Broad-spectrum antivirals (BSAs) are agents that inhibit replication of several human viruses. Here, we review 108 approved, investigational, and experimental BSAs, for which safety profiles in humans are available. The most effective and tolerable BSAs could reinforce the arsenal of available antiviral therapeutics pending the results of further pre-clinical and clinical studies.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Antiviral Agents* / chemistry
Antiviral Agents* / pharmacology
Antiviral Agents* / therapeutic use
Drug Discovery
Drug Repositioning
Humans
Viruses / drug effects

Substances

Antiviral Agents