Simultaneous delivery of gene and chemotherapeutics via copolymeric micellar nanoparticles to overcome multiple drug resistance to promote synergistic tumor suppression

J Biomater Appl. 2019 Jul;34(1):130-140. doi: 10.1177/0885328219839254. Epub 2019 Apr 10.

Jianguo Gao¹, Lingxiao Chen², Ruogu Qi³, Zhihua Zhou⁴, Zaian Deng⁵, Jue Shi⁵, Tao Qin⁵, Shengzhe Zhao⁶, Yuna Qian^{5

6}, Jianliang Shen^{5

6}

¹ 1 Department of Urology, Affiliated Hospital of Huzhou Teacher's College, The First People's Hospital of Hu Zhou, Hu Zhou, China.
² 2 Department of Urology, Xiangya Hospital, Central South University, Changsha, China.
³ 3 State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Changchun, China.
⁴ 4 School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, China.
⁵ 5 School of Ophthalmology & Optometry, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou, China.
⁶ 6 Wenzhou Institute of Biomaterials and Engineering, Chinese Academy of Science, Wenzhou, China.

No abstract available

Keywords: Micellar nanoparticle; co-delivery; multiple drug resistance; siRNA; synergistic effect.

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