Children Are Not Small Adults: Specific Findings in Statin Exposure and Response in a Growing Population

Clin Pharmacol Ther. 2019 Aug;106(2):278-280. doi: 10.1002/cpt.1431. Epub 2019 Apr 10.
No abstract available

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Child
  • Child Development / physiology
  • Genetic Association Studies
  • Humans
  • Hydroxymethylglutaryl CoA Reductases / genetics*
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors* / pharmacokinetics
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors* / therapeutic use
  • Hypercholesterolemia* / drug therapy
  • Hypercholesterolemia* / genetics
  • Liver-Specific Organic Anion Transporter 1 / genetics*
  • Medication Therapy Management / standards
  • Pediatrics / methods
  • Pediatrics / standards
  • Pharmacogenetics
  • Pharmacogenomic Variants

Substances

  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Liver-Specific Organic Anion Transporter 1
  • SLCO1B1 protein, human
  • HMGCR protein, human
  • Hydroxymethylglutaryl CoA Reductases