Formulation of Carbopol®/Poly(2-ethyl-2-oxazoline)s Mucoadhesive Tablets for Buccal Delivery of Hydrocortisone

Leire Ruiz-Rubio; María Luz Alonso; Leyre Pérez-Álvarez; Rosa Maria Alonso; Jose Luis Vilas; Vitaliy V Khutoryanskiy

doi:10.3390/polym10020175

Formulation of Carbopol^®/Poly(2-ethyl-2-oxazoline)s Mucoadhesive Tablets for Buccal Delivery of Hydrocortisone

Polymers (Basel). 2018 Feb 11;10(2):175. doi: 10.3390/polym10020175.

Authors

Leire Ruiz-Rubio¹, María Luz Alonso², Leyre Pérez-Álvarez³, Rosa Maria Alonso⁴, Jose Luis Vilas⁵, Vitaliy V Khutoryanskiy⁶

Affiliations

¹ Macromolecular Chemistry Group (LABQUIMAC), Department of Physical Chemistry, Faculty of Science and Technology, University of the Basque Country, UPV/EHU, Barrio Sarriena, s/n, 48940 Leioa, Spain. leire.ruiz@ehu.eus.
² Analytical Chemistry Department, Faculty of Science and Technology, University of the Basque Country, UPV/EHU, Barrio Sarriena, s/n, 48940 Leioa, Spain. marialuz.alonso@ehu.eus.
³ Macromolecular Chemistry Group (LABQUIMAC), Department of Physical Chemistry, Faculty of Science and Technology, University of the Basque Country, UPV/EHU, Barrio Sarriena, s/n, 48940 Leioa, Spain. leyre.perez@ehu.eus.
⁴ Analytical Chemistry Department, Faculty of Science and Technology, University of the Basque Country, UPV/EHU, Barrio Sarriena, s/n, 48940 Leioa, Spain. rosamaria.alonso@ehu.eus.
⁵ Macromolecular Chemistry Group (LABQUIMAC), Department of Physical Chemistry, Faculty of Science and Technology, University of the Basque Country, UPV/EHU, Barrio Sarriena, s/n, 48940 Leioa, Spain. joseluis.vilas@ehu.es.
⁶ School of Pharmacy, University of Reading, Whiteknights, P.O. Box 224, Reading RG6 6AD, UK. v.khutoryanskiy@reading.ac.uk.

Abstract

Poly(2-ethyl-2-oxazoline) has become an excellent alternative to the use of poly(ethylene glycol) in pharmaceutical formulations due to its valuable physicochemical and biological properties. This work presents a formulation of poorly-water soluble drug, hydrocortisone, using interpolymer complexes and physical blends of poly(2-ethyl-2-oxazoline)s and two Carbopols^® (Carbopol 974 and Carbopol 971) for oromucosal administration. The swelling, hydrocortisone release and mucoadhesive properties of a series of tablet formulations obtained by combination of different Carbopols with poly(2-ethyl-2-oxazoline)s of different molecular weights have been evaluated in vitro.

Keywords: Carbopol®; interpolymer complexes; mucoadhesion; poly(2-ethyl-2-oxazoline).