New Dammarane-type Saponins from Gynostemma pentaphyllum

Po-Yen Chen; Chih-Chao Chang; Hui-Chi Huang; Li-Jie Zhang; Chia-Ching Liaw; Yu-Chi Lin; Nham-Linh Nguyen; Thanh-Hoa Vo; Yung-Yi Cheng; Susan L Morris-Natschke; Kuo-Hsiung Lee; Yao-Haur Kuo

doi:10.3390/molecules24071375

New Dammarane-type Saponins from Gynostemma pentaphyllum

Molecules. 2019 Apr 8;24(7):1375. doi: 10.3390/molecules24071375.

Authors

Po-Yen Chen^{1

2}, Chih-Chao Chang³, Hui-Chi Huang⁴, Li-Jie Zhang⁵, Chia-Ching Liaw⁶, Yu-Chi Lin⁷, Nham-Linh Nguyen^{8

9}, Thanh-Hoa Vo^{10

11}, Yung-Yi Cheng^{12

13}, Susan L Morris-Natschke¹⁴, Kuo-Hsiung Lee^{15

16}, Yao-Haur Kuo^{17

18

19}

Affiliations

¹ Division of Chinese Materia Medica Development, National Research Institute of Chinese Medicine, Taipei 112, Taiwan. peik35@gmail.com.
² Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei 112, Taiwan. peik35@gmail.com.
³ Division of Chinese Materia Medica Development, National Research Institute of Chinese Medicine, Taipei 112, Taiwan. changhcym@gmail.com.
⁴ Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan. m8952612@hotmail.com.
⁵ Division of Chinese Materia Medica Development, National Research Institute of Chinese Medicine, Taipei 112, Taiwan. lijizhang@hotmail.com.
⁶ Department of Research and Development, Starsci Biotech Co. Ltd., Taipei 112, Taiwan. biogodas@hotmail.com.
⁷ Division of Chinese Materia Medica Development, National Research Institute of Chinese Medicine, Taipei 112, Taiwan. hchuang@mail.cmu.edu.tw.
⁸ Division of Chinese Materia Medica Development, National Research Institute of Chinese Medicine, Taipei 112, Taiwan. nguyenlinhnham4201@gmail.com.
⁹ The Ph.D. program in Clinical Drug Development of Chinese Herbal Medicine, College of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan. nguyenlinhnham4201@gmail.com.
¹⁰ Division of Chinese Materia Medica Development, National Research Institute of Chinese Medicine, Taipei 112, Taiwan. hoavo0808@gmail.com.
¹¹ The Ph.D. program in Clinical Drug Development of Chinese Herbal Medicine, College of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan. hoavo0808@gmail.com.
¹² Natural Products Research Laboratories, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599-7568, USA. yungyi@email.unc.edu.
¹³ Chinese Medicine Research and Development Center, China Medical University and Hospital, Taichung 40402, Taiwan. yungyi@email.unc.edu.
¹⁴ Natural Products Research Laboratories, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599-7568, USA. susan_natschke@unc.edu.
¹⁵ Natural Products Research Laboratories, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599-7568, USA. yhlee@unc.edu.
¹⁶ Chinese Medicine Research and Development Center, China Medical University and Hospital, Taichung 40402, Taiwan. yhlee@unc.edu.
¹⁷ Division of Chinese Materia Medica Development, National Research Institute of Chinese Medicine, Taipei 112, Taiwan. kuoyh@nricm.edu.tw.
¹⁸ The Ph.D. program in Clinical Drug Development of Chinese Herbal Medicine, College of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan. kuoyh@nricm.edu.tw.
¹⁹ Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung 404, Taiwan. kuoyh@nricm.edu.tw.

Abstract

Six new dammarane-type saponins, gypenosides CP1-6 (16), along with 19 known compounds 7⁻25, were isolated and characterized from the aerial parts of Gynostemma pentaphyllum. Among these compounds, eight dammarane-type saponins, 2, 5, 6, 7, 11, 12, 13, and 15, exhibited the greatest antiproliferative effects against two human tumor cell lines (A549 and HepG2).

Keywords: Gynostemma pentaphyllum; Jiaogulan; dammarane-type saponins; gypenosides antiproliferative activity.

MeSH terms

A549 Cells
Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / isolation & purification*
Antineoplastic Agents, Phytogenic / pharmacology
Cell Proliferation / drug effects
Dammaranes
Gynostemma / chemistry*
Hep G2 Cells
Humans
Molecular Structure
Plant Components, Aerial / chemistry
Plant Extracts / chemistry
Saponins / chemistry
Saponins / isolation & purification*
Saponins / pharmacology
Triterpenes

Substances

Antineoplastic Agents, Phytogenic
Plant Extracts
Saponins
Triterpenes