Chemical Constituents of Vigna luteola and Their Anti-inflammatory Bioactivity

Sio-Hong Lam; Yue-Chiun Li; Ping-Chung Kuo; Tsong-Long Hwang; Mei-Lin Yang; Chien-Chiao Wang; Jason T C Tzen

doi:10.3390/molecules24071371

Chemical Constituents of Vigna luteola and Their Anti-inflammatory Bioactivity

Molecules. 2019 Apr 8;24(7):1371. doi: 10.3390/molecules24071371.

Authors

Sio-Hong Lam¹, Yue-Chiun Li², Ping-Chung Kuo³, Tsong-Long Hwang^{4

5

6}, Mei-Lin Yang⁷, Chien-Chiao Wang⁸, Jason T C Tzen⁹

Affiliations

¹ School of Pharmacy, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan. shlam@mail.ncku.edu.tw.
² Graduate Institute of Biotechnology, National Chung-Hsing University, Taichung 402, Taiwan. ycli0126@gmail.com.
³ School of Pharmacy, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan. z10502016@email.ncku.edu.tw.
⁴ Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan. htl@mail.cgu.edu.tw.
⁵ Research Center for Industry of Human Ecology, Research Center for Chinese Herbal Medicine, and Graduate Institute of Health Industry Technology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan. htl@mail.cgu.edu.tw.
⁶ Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan. htl@mail.cgu.edu.tw.
⁷ School of Pharmacy, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan. L3891104@nckualumni.org.tw.
⁸ Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan. D0501502@cgu.edu.tw.
⁹ Graduate Institute of Biotechnology, National Chung-Hsing University, Taichung 402, Taiwan. tctzen@dragon.nchu.edu.tw.

Abstract

Seventy-three compounds were identified from the methanol extract of V. luteola, and among these, three new (1⁻3) were characterized by spectroscopic and mass spectrometric analyses. The isolated constituents were assessed for anti-inflammatory potential evaluation, and several purified principles exhibited significant superoxide anion and elastase inhibitory effects.

Keywords: elastase release; fabaceae; sesquiterpenoid; superoxide anion generation.

MeSH terms

Anti-Inflammatory Agents / chemistry
Anti-Inflammatory Agents / isolation & purification
Anti-Inflammatory Agents / pharmacology*
Cytochalasin B / adverse effects
Humans
Magnetic Resonance Spectroscopy
Mass Spectrometry
Neutrophils / drug effects
Neutrophils / metabolism
Pancreatic Elastase / antagonists & inhibitors
Phytochemicals / chemistry
Phytochemicals / isolation & purification
Phytochemicals / pharmacology*
Superoxides / antagonists & inhibitors
Vigna / chemistry*

Substances

Anti-Inflammatory Agents
Phytochemicals
Superoxides
Cytochalasin B
Pancreatic Elastase

Abstract

MeSH terms

Substances

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