Sorting Out Fate Determination

Mostafa Bakhti; Aimée Bastidas-Ponce; Heiko Lickert

doi:10.1016/j.devcel.2019.03.020

Sorting Out Fate Determination

Dev Cell. 2019 Apr 8;49(1):1-3. doi: 10.1016/j.devcel.2019.03.020.

Authors

Mostafa Bakhti¹, Aimée Bastidas-Ponce², Heiko Lickert³

Affiliations

¹ Institute of Diabetes and Regeneration Research, Helmholtz Zentrum München, Neuherberg, Germany; Institute of Stem Cell Research, Helmholtz Zentrum München, Neuherberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany.
² Institute of Diabetes and Regeneration Research, Helmholtz Zentrum München, Neuherberg, Germany; Institute of Stem Cell Research, Helmholtz Zentrum München, Neuherberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany; Technical University of Munich, Medical Faculty, Munich, Germany.
³ Institute of Diabetes and Regeneration Research, Helmholtz Zentrum München, Neuherberg, Germany; Institute of Stem Cell Research, Helmholtz Zentrum München, Neuherberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany; Technical University of Munich, Medical Faculty, Munich, Germany. Electronic address: heiko.lickert@helmholtz-muenchen.de.

PMID: 30965032
DOI: 10.1016/j.devcel.2019.03.020

Abstract

How organ morphogenesis specifies cell fate and whether organ progenitors are predetermined or specified via niche signals are critical developmental biology questions. In this issue of Developmental Cell, Nyeng et al. (2019) modulate cell-cell adhesion in the pancreas and provide evidence that progenitors are plastic and instructed by niche signals.

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MeSH terms

Catenins
Cell Differentiation
Cell Movement
Delta Catenin
Morphogenesis
Pancreas*

Substances

Catenins
Delta Catenin