Animal Models of Osteoarthritis in Small Mammals

C Iván Serra; Carme Soler

doi:10.1016/j.cvex.2019.01.004

Animal Models of Osteoarthritis in Small Mammals

Vet Clin North Am Exot Anim Pract. 2019 May;22(2):211-221. doi: 10.1016/j.cvex.2019.01.004.

Authors

C Iván Serra¹, Carme Soler²

Affiliations

¹ Department of Animal Medicine and Surgery, UCV Veterinary Hospital, Faculty of Veterinary and Experimental Sciences, Universidad Católica de Valencia San Vicente Mártir, Valencia, Spain. Electronic address: ci.serra@ucv.es.
² Department of Animal Medicine and Surgery, UCV Veterinary Hospital, Faculty of Veterinary and Experimental Sciences, Universidad Católica de Valencia San Vicente Mártir, Valencia, Spain.

PMID: 30961898
DOI: 10.1016/j.cvex.2019.01.004

Abstract

Osteoarthritis (OA) affects the synovial joint. Animal models commonly used to study the disease and its therapeutic treatment are generally spontaneous or induced. The lack of an animal model representing all types of existing OA requires knowledge about what can be expected from each species and their limitations. The choice of species is crucial, as the selection of the age of individuals at the start of a study, their sex, and nutritional and environmental conditions. A better understanding of the small mammal models used for the study of osteoarthritic pathology may benefit both researcher and clinician dealing with these animals.

Keywords: Animal model; Guinea pig; Mouse; Osteoarthritis; Rabbit; Rat.

Publication types

Review

MeSH terms

Animals
Disease Models, Animal*
Guinea Pigs
Mammals*
Mice
Osteoarthritis / veterinary*
Rabbits
Rats