Two new compounds from the marine sponge derived fungus Penicillium chrysogenum

Xiao Han; Pinglin Li; Xiangchao Luo; Dan Qiao; Xuli Tang; Guoqiang Li

doi:10.1080/14786419.2019.1598994

Two new compounds from the marine sponge derived fungus Penicillium chrysogenum

Nat Prod Res. 2020 Oct;34(20):2926-2930. doi: 10.1080/14786419.2019.1598994. Epub 2019 Apr 8.

Authors

Xiao Han^{1

2}, Pinglin Li^{1

2}, Xiangchao Luo^{1

2}, Dan Qiao^{1

2}, Xuli Tang³, Guoqiang Li^{1

2}

Affiliations

¹ School of Medicine and Pharmacy, Ocean University of China, Qingdao, China.
² Laboratory of Marine Drugs and Biological Products, National Laboratory for Marine Science and Technology, Qingdao, China.
³ College of Chemistry and Chemical Engineering, Ocean University of China, Qingdao, China.

PMID: 30957554
DOI: 10.1080/14786419.2019.1598994

Abstract

Two new compounds (1 and 2) were isolated from the marine sponge derived fungus Penicillium chrysogenum by using various column chromatography techniques. Their structures were elucidated by extensive analysis of spectroscopic data and quantum chemical calculation. Compound 1 exhibited moderate activity against PTP1B with 2.95 ± 0.97% at the concentration of 30 μmol·L^-1.

Keywords: Marine sponge; PTP1B activity; Penicillium chrysogenum; fungus.

MeSH terms

Animals
Enzyme Inhibitors / isolation & purification
Molecular Structure
Penicillium chrysogenum / chemistry*
Porifera / microbiology*
Protein Tyrosine Phosphatase, Non-Receptor Type 1 / antagonists & inhibitors*

Substances

Enzyme Inhibitors
Protein Tyrosine Phosphatase, Non-Receptor Type 1