Gap 2 phase: making the fundamental decision to divide or not

Masaaki Umeda; Shiori S Aki; Naoki Takahashi

doi:10.1016/j.pbi.2019.03.001

Gap 2 phase: making the fundamental decision to divide or not

Curr Opin Plant Biol. 2019 Oct:51:1-6. doi: 10.1016/j.pbi.2019.03.001. Epub 2019 Apr 5.

Authors

Masaaki Umeda¹, Shiori S Aki², Naoki Takahashi²

Affiliations

¹ Graduate School of Science and Technology, Nara Institute of Science and Technology, Takayama 8916-5, Ikoma, Nara 630-0192, Japan. Electronic address: mumeda@bs.naist.jp.
² Graduate School of Science and Technology, Nara Institute of Science and Technology, Takayama 8916-5, Ikoma, Nara 630-0192, Japan.

PMID: 30954849
DOI: 10.1016/j.pbi.2019.03.001

Abstract

The Gap phases of the cell cycle are essential to perceive internal and external signals and control cell division and differentiation. However, our knowledge of molecular mechanisms underlying G2 progression in plants remains quite limited. In this review, we summarize recent findings about core G2-phase regulators, such as B-type cyclin-dependent kinases (CDKs) and R1R2R3-type MYB transcription factors. We highlight developmental and stress signals that regulate expression and accumulation of the G2-phase regulators, and discuss how they fine-tune mitotic CDK activity and control cell proliferation, endoreplication and cell cycle checkpoints. A particular focus is on DNA damage-induced G2 arrest, which is prerequisite for maintenance of genome stability.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Cell Cycle
Cell Division
Cyclin-Dependent Kinases*
DNA Damage*
Transcription Factors

Substances

Transcription Factors
Cyclin-Dependent Kinases