Severe Asthma in Childhood

Immunol Allergy Clin North Am. 2019 May;39(2):243-257. doi: 10.1016/j.iac.2018.12.007.

Abstract

Severe asthma is broadly defined as asthma requiring a high level of therapy, usually high doses of inhaled corticosteroids, to bring under control. Children who remain symptomatic despite such treatment are a heterogeneous population, and bear a high burden of disease and require high resource utilization. Children with severe asthma require a comprehensive evaluation, careful consideration of alternative diagnoses and comorbid conditions, assessment of medication adherence and environmental conditions, and frequent disease monitoring.

Keywords: Children; Management; Phenotype; Severe asthma.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adrenal Cortex Hormones / therapeutic use*
  • Anti-Asthmatic Agents / therapeutic use*
  • Asthma / diagnosis*
  • Asthma / therapy
  • Child
  • Child, Preschool
  • Disease Progression
  • Humans
  • Interdisciplinary Communication
  • Phenotype
  • Severity of Illness Index

Substances

  • Adrenal Cortex Hormones
  • Anti-Asthmatic Agents