Enteral Access Potentially Endangers Esophageal Carcinoma Patients Under Multi-modality Therapy: A Population-based Study

Anticancer Res. 2019 Apr;39(4):2227-2232. doi: 10.21873/anticanres.13338.

Abstract

Background/aim: This study aimed to evaluate the clinical outcome of esophageal cancer (EC) patients with enteral access (EA) undergoing multimodality therapy.

Patients and methods: This retrospective study analyzed data between 1997 and 2012 in Taiwan using the National Health Insurance Research Database. Patients with newly-diagnosed EC undergoing multimodality therapy were identified and classified as either EA group or no-EA group.

Results: The mortality incidence of EC patients with EA was significantly higher than in no-EA patients. The Cox model revealed the EA group had a higher risk of mortality than the no-EA group. Patients with chronic obstructive pulmonary disease (COPD) were at significantly higher risk of mortality compared to patients without COPD.

Conclusion: EA in EC patients undergoing multimodality therapy was associated with an increased risk of mortality.

Keywords: Enteral access; esophageal cancer; multi-modality therapy; nutritional treatment.

MeSH terms

  • Adult
  • Aged
  • Chemoradiotherapy
  • Combined Modality Therapy
  • Digestive System Surgical Procedures
  • Enteral Nutrition*
  • Esophageal Neoplasms / mortality*
  • Esophageal Neoplasms / therapy*
  • Esophageal Squamous Cell Carcinoma / mortality*
  • Esophageal Squamous Cell Carcinoma / therapy*
  • Female
  • Humans
  • Kaplan-Meier Estimate
  • Male
  • Middle Aged
  • Proportional Hazards Models
  • Retrospective Studies