RALying Regeneration through Wnt Internalization in Stem Cells

Helen Tauc; Heinrich Jasper

doi:10.1016/j.stem.2019.03.008

RALying Regeneration through Wnt Internalization in Stem Cells

Cell Stem Cell. 2019 Apr 4;24(4):499-500. doi: 10.1016/j.stem.2019.03.008.

Authors

Helen Tauc¹, Heinrich Jasper²

Affiliations

¹ Immunology Discovery, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
² Immunology Discovery, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA. Electronic address: jasperh@gene.com.

PMID: 30951654
DOI: 10.1016/j.stem.2019.03.008

Abstract

In this issue of Cell Stem Cell, Johansson et al. (2019) find evolutionarily conserved regulation of Wnt signaling through Ral GTPases. These GTPases promote internalization of Wnt receptor complexes and play a critical role in intestinal stem cell function in flies and mice.

Publication types

Comment

MeSH terms

Animals
GTP Phosphohydrolases
Mice
Regeneration*
Stem Cells
Wnt Signaling Pathway*

Substances

GTP Phosphohydrolases