Triclosan (TCS) is an effective broad-spectrum antimicrobial agent that is widely used in personal care products. It has been detected in different environmental media, and poses high potential ecological risk. In this article, we carried out a literature review of recent studies on the toxic effects of TCS from different aspects at the molecular, cell, tissue, organ, and individual level. TCS can exhibit acute toxicity to aquatic organisms, affect the normal expression and physiological function of enzymes and genes, and produce cytotoxicity. Many studies have demonstrated that TCS exerts significant endocrine-disrupting effects on organisms, interfering the normal physiological functions of the reproductive, thyroid, and nervous systems via related signaling pathways. Moreover, we reported current research on the water quality criteria of TCS and discuss possible future research directions.
Keywords: Cytotoxicity; Endocrine-disrupting effect; Toxic effect; Triclosan; Water quality criteria.