Sarcoidosis and the Liver

Manoj Kumar; Jorge L Herrera

doi:10.1016/j.cld.2018.12.012

Sarcoidosis and the Liver

Clin Liver Dis. 2019 May;23(2):331-343. doi: 10.1016/j.cld.2018.12.012. Epub 2019 Mar 2.

Authors

Manoj Kumar¹, Jorge L Herrera²

Affiliations

¹ Division of Gastroenterology, University of South Alabama College of Medicine, UCOM 6000, 75 University Boulevard South, Mobile, AL 36688, USA.
² Division of Gastroenterology, University of South Alabama College of Medicine, UCOM 6000, 75 University Boulevard South, Mobile, AL 36688, USA. Electronic address: jherrera18@gmail.com.

PMID: 30947880
DOI: 10.1016/j.cld.2018.12.012

Abstract

Hepatic granulomas are a common finding in systemic sarcoidosis, but most patients remain asymptomatic. Elevated alkaline phosphatase is the most common sign of hepatic sarcoidosis (HS). Lacking a specific diagnostic test, the diagnosis of HS is one of exclusion. Therapy may be indicated in a minority of patients to control symptoms, but the effects of therapy in the natural history of HS are unknown.

Keywords: Granuloma; Hepatitis; Liver; Sarcoidosis.

Publication types

Review

MeSH terms

Adrenal Cortex Hormones / therapeutic use
Cholagogues and Choleretics / therapeutic use
Diagnosis, Differential
Humans
Liver Diseases / diagnosis*
Liver Diseases / etiology*
Liver Diseases / pathology
Liver Diseases / therapy
Liver Transplantation
Sarcoidosis / diagnosis*
Sarcoidosis / etiology*
Sarcoidosis / pathology
Sarcoidosis / therapy
Ursodeoxycholic Acid / therapeutic use

Substances

Adrenal Cortex Hormones
Cholagogues and Choleretics
Ursodeoxycholic Acid