Renoprotective phenolic meroterpenoids from the mushroom Ganoderma cochlear

Phytochemistry. 2019 Jun:162:199-206. doi: 10.1016/j.phytochem.2019.03.019. Epub 2019 Apr 1.

Abstract

Twelve previously undescribed phenolic meroterpenoids, cochlearols N-Y, along with two known analogs, ganocochlearins B and C, were isolated from the fruiting bodies of Ganoderma cochlear. Most of these substances were isolated as racemic mixtures. The structures of cochlearols N-Y were assigned based upon spectroscopic data and theoretical calculations. The renoprotective activities of these compounds were evaluated using normal and diseased rat renal interstitial fibroblast cells (NRK-49F). The results show that ganocochlearins S, U, X and Y display potent inhibitory activities against fibronectin overproduction in TGF-β1-induced NRK-49F cells.

Keywords: Calculated ECD; Ganoderma cochlear (Ganodermataceae); Meroterpenoid; Renoprotection.

MeSH terms

  • Animals
  • Cell Line
  • Cytoprotection / drug effects*
  • Fruiting Bodies, Fungal / chemistry
  • Ganoderma / chemistry*
  • Kidney / cytology*
  • Kidney / drug effects
  • Models, Molecular
  • Molecular Conformation
  • Phenols / chemistry*
  • Rats
  • Terpenes / chemistry*
  • Terpenes / pharmacology*

Substances

  • Phenols
  • Terpenes