When interacting with supervisors, employees often engage in emotion regulation (i.e., surface acting and deep acting), and the consequences may extend beyond work boundaries. Based on the spillover-crossover model and the strength model of self-control, we examined the relationship between employee emotion regulation during supervisory interactions and marital well-being (i.e., spouse's perceived marriage quality and satisfaction). Two survey studies using Chinese employee-spouse dyads showed that employees' surface acting was positively related to ego depletion. Surface acting was found to be negatively related to spouses' perceived marital well-being through the serial mediating roles of both ego depletion and social undermining behavior. Moreover, leader-member exchange (LMX) relationship quality moderated the association between surface acting and ego depletion such that the relationship was weaker for employees with a high-quality LMX relationship compared with those with a low-quality LMX relationship. These findings extend theory and research on emotion regulation to employee-leader interactions and contribute to future research and theory-building on emotion regulation, leadership, and work-family integration. Practical implications for leaders, organizations, and employees were discussed. (PsycINFO Database Record (c) 2019 APA, all rights reserved).