Gut T Cells Feast on GLP-1 to Modulate Cardiometabolic Disease

Sue Tsai; Shawn Winer; Daniel A Winer

doi:10.1016/j.cmet.2019.03.002

Gut T Cells Feast on GLP-1 to Modulate Cardiometabolic Disease

Cell Metab. 2019 Apr 2;29(4):787-789. doi: 10.1016/j.cmet.2019.03.002.

Authors

Sue Tsai¹, Shawn Winer², Daniel A Winer³

Affiliations

¹ Division of Cellular & Molecular Biology, Diabetes Research Group, Toronto General Hospital Research Institute (TGHRI), University Health Network, Toronto, ON M5G 1L7, Canada; Department of Medical Microbiology and Immunology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB T6G 2S2, Canada.
² Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A8, Canada; Department of Laboratory Medicine, St. Michael's Hospital, Toronto, ON M5B 1W8, Canada.
³ Division of Cellular & Molecular Biology, Diabetes Research Group, Toronto General Hospital Research Institute (TGHRI), University Health Network, Toronto, ON M5G 1L7, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A8, Canada; Department of Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada; Department of Pathology, University Health Network, Toronto, ON M5G 2C4, Canada; Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA. Electronic address: dan.winer@uhn.ca.

PMID: 30943389
DOI: 10.1016/j.cmet.2019.03.002

Abstract

Glucagon-like peptide-1 (GLP-1) is an enteroendocrine hormone that controls insulin secretion, intestinal function, and food intake. Recently in Nature, He et al. (2019) reported that gut intraepithelial T cells regulate GLP-1 bioavailability by capturing it on GLP-1 receptors and impacting L-cell numbers. This study delineates a novel endocrine-immune axis through which intestinal immune cells regulate whole-body metabolism.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Cardiovascular Diseases*
Enteroendocrine Cells
Glucagon-Like Peptide 1
Humans
Intestines
Intraepithelial Lymphocytes*
Male

Substances

Glucagon-Like Peptide 1

Grants and funding

FDN-148385/CIHR/Canada