Metabolic Adaptation Fuels Lymph Node Metastasis

Jessalyn M Ubellacker; Sean J Morrison

doi:10.1016/j.cmet.2019.03.006

Metabolic Adaptation Fuels Lymph Node Metastasis

Cell Metab. 2019 Apr 2;29(4):785-786. doi: 10.1016/j.cmet.2019.03.006.

Authors

Jessalyn M Ubellacker¹, Sean J Morrison²

Affiliations

¹ Children's Research Institute and Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
² Children's Research Institute and Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: sean.morrison@utsouthwestern.edu.

PMID: 30943388
DOI: 10.1016/j.cmet.2019.03.006

Abstract

Many cancers metastasize regionally through lymphatics before metastasizing systemically through blood vessels. However, metastasis through blood has been studied much more extensively than metastasis through lymph. Recently in Science, Lee et al. (2019) offered new insight into lymph node metastasis by showing that melanoma cells must undergo metabolic changes during this process and that it is driven by localized accumulation of bile acids.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Comment

MeSH terms

Humans
Lymph Nodes
Lymphangiogenesis
Lymphatic Metastasis
Lymphatic Vessels*
Skin Neoplasms*

Grants and funding

HHMI/Howard Hughes Medical Institute/United States