Visible light mediated oxidative lactonization of 2-methyl-1,1'-biaryls for the synthesis of benzocoumarins

Org Biomol Chem. 2019 Apr 24;17(17):4212-4215. doi: 10.1039/c9ob00529c.

Abstract

A visible light mediated oxidative lactonization of 2-methyl-1,1'-biaryls was developed, giving benzocoumarins in good yields. The reaction features multiple C-H functionalization processes with oxygen as the final oxidant. The corresponding 2-aldehdyes, alcohols and carboxylic acids of the 1,1'-biaryls also worked well for the reaction.

Publication types

  • Research Support, Non-U.S. Gov't