Abstract
New drugs introduced to the market every year represent privileged structures for particular biological targets. These new chemical entities (NCEs) provide insight into molecular recognition while serving as leads for designing future new drugs. This annual review describes the most likely process-scale synthetic approaches to 31 new chemical entities approved for the first time globally in 2017.
MeSH terms
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Anti-Infective Agents / chemical synthesis
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Anti-Infective Agents / chemistry
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry
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Drug Approval*
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Drug Design*
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Gastrointestinal Agents / chemical synthesis
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Gastrointestinal Agents / chemistry
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Hematologic Agents / chemical synthesis
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Hematologic Agents / chemistry
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Models, Chemical*
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Molecular Structure
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Ophthalmic Solutions / chemical synthesis
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Ophthalmic Solutions / chemistry
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Pharmaceutical Preparations / chemical synthesis*
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Pharmaceutical Preparations / chemistry
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Pharmaceutical Preparations / classification
Substances
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Anti-Infective Agents
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Antineoplastic Agents
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Gastrointestinal Agents
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Hematologic Agents
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Ophthalmic Solutions
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Pharmaceutical Preparations