The purpose of this study was to investigate relationships between four emotion regulation strategies (intrinsic affect-improving, intrinsic affect-worsening, extrinsic affect-improving, and extrinsic affect-worsening) and compassion fatigue, job satisfaction, and life satisfaction among 90 hospice nurses who completed an online survey. Intrinsic affect-improving was associated with higher life satisfaction. Intrinsic affect-worsening was associated with higher compassion fatigue and lower life satisfaction. Extrinsic affect-worsening was associated with lower job satisfaction. Overall, these findings support a multidimensional approach to understanding emotion regulation among hospice nurses.