Thoracic Radiography Characteristics of Drug Sensitive Tuberculosis and Multi Drug Resistant Tuberculosis: A Study of Indonesian National Tuberculosis Prevalence Survey

Acta Medica (Hradec Kralove). 2019;62(1):24-29. doi: 10.14712/18059694.2019.42.

Abstract

Background: Tuberculosis (TB) remains a burden globally, including Indonesia. The primary objective of this study is to reveal the chest radiography characteristic of drug-sensitive TB (DS-TB) and multi-drug resistant TB (MDR-TB) in the Indonesian national tuberculosis prevalence survey 2013-2014. The secondary objective is to explore the correlation and incidence rate of chest radiography lesion of DS-TB and MDR-TB cases.

Methods: This is a cross-sectional retrospective analytical studies with national and regional coverage. Samples were selected by stratified multi-stage clustering sampling technique in a population aged ≥15 years old. The diagnosis of TB was based on culture and GeneXpert tests.

Results: There were 147 DS-TB and 11 MDR-TB patients that were analyzed in this study. The nodule is the only type of lesions that distinguish MDR-TB and DS-TB. In multivariate analysis of DS-TB, there were 3 significant chest radiography lesions, i.e infiltrate, cavity and consolidation with odd-ratio (OR) of 14, 13, and 3, respectively. In MDR-TB, the only significant lesion is a nodule, with OR of 19.

Conclusion: Nodule is the only type of lesions that distinguish MDR-TB and DS-TB. Infiltrate, cavity and consolidation were the types of chest radiography lesions on DS-TB, meanwhile, a nodule was the only significant lesion for MDR-TB.

Keywords: DS-TB; MDR-TB; chest radiography; tuberculosis.

MeSH terms

  • Adolescent
  • Adult
  • Cross-Sectional Studies
  • Drug Resistance, Bacterial / drug effects*
  • Female
  • Health Surveys*
  • Humans
  • Image Processing, Computer-Assisted
  • Indonesia / epidemiology
  • Lung / diagnostic imaging*
  • Lung / pathology
  • Male
  • Middle Aged
  • Prevalence
  • Radiography, Thoracic*
  • Retrospective Studies
  • Tuberculosis, Multidrug-Resistant / diagnostic imaging*
  • Tuberculosis, Multidrug-Resistant / epidemiology
  • Tuberculosis, Multidrug-Resistant / microbiology*
  • Tuberculosis, Multidrug-Resistant / pathology
  • Young Adult