Abstract
Two new compounds Talaromycin A (1) and Talaromycin B (2) were isolated from a liquid culture of Talaromyces aurantiacus. The structures of 1 and 2 were elucidated by IR, MS, 1D and 2D NMR spectra and comparison of the experimental and calculated electronic circular dichroism spectra. Additional known compounds (3-6) were also isolated. These compounds were tested for monoamine oxidase, acetylcholinesterase and PI3K inhibitory activity, but showed only weak activity.
Keywords:
Talaromyces aurantiacus; Endophytic fungus; structure elucidation.
MeSH terms
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Cholinesterase Inhibitors / chemistry
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Cholinesterase Inhibitors / pharmacology
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Circular Dichroism
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Drug Evaluation, Preclinical
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Endophytes / chemistry
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Enzyme Inhibitors / chemistry*
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Enzyme Inhibitors / isolation & purification
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Enzyme Inhibitors / pharmacology*
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Monoamine Oxidase Inhibitors / chemistry
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Monoamine Oxidase Inhibitors / pharmacology
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Phosphoinositide-3 Kinase Inhibitors / chemistry
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Phosphoinositide-3 Kinase Inhibitors / pharmacology
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Spiro Compounds / chemistry*
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Spiro Compounds / isolation & purification
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Spiro Compounds / pharmacology
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Talaromyces / chemistry*
Substances
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Cholinesterase Inhibitors
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Enzyme Inhibitors
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Monoamine Oxidase Inhibitors
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Phosphoinositide-3 Kinase Inhibitors
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Spiro Compounds
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talaromycin B