The structure of TRPC ion channels

Jian Li; Xu Zhang; Xiaojing Song; Rui Liu; Jin Zhang; Zongli Li

doi:10.1016/j.ceca.2019.03.005

The structure of TRPC ion channels

Cell Calcium. 2019 Jun:80:25-28. doi: 10.1016/j.ceca.2019.03.005. Epub 2019 Mar 14.

Authors

Jian Li¹, Xu Zhang², Xiaojing Song², Rui Liu², Jin Zhang³, Zongli Li⁴

Affiliations

¹ College of Pharmaceutical Sciences, Gannan Medical University, Ganzhou, Jiangxi, 341000, China; Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of Education, Ganan Medical University, Ganzhou, 341000, China.
² School of Basic Medical Sciences, Nanchang University, Nanchang, Jiangxi, 330031, China.
³ School of Basic Medical Sciences, Nanchang University, Nanchang, Jiangxi, 330031, China. Electronic address: zhangxiaokong@hotmail.com.
⁴ Howard Hughes Medical Institute, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, USA. Electronic address: zongli_li@hms.harvard.edu.

PMID: 30928685
DOI: 10.1016/j.ceca.2019.03.005

Abstract

Briefly review the recent structural work of transient receptor potential canonical (TRPC) ion channels by using electron cryo-microscopy (cryo-EM). The high resolution structures of TRPC3, TRPC4, TRPC5 and TRPC6 are discussed.

Keywords: Cryo-EM; TRPC.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Amino Acid Motifs / genetics
Animals
Calcium / metabolism*
Calcium Signaling
Cryoelectron Microscopy / methods*
Humans
Porins / genetics
Protein Conformation
Structure-Activity Relationship
Transient Receptor Potential Channels / chemistry
Transient Receptor Potential Channels / genetics
Transient Receptor Potential Channels / metabolism*

Substances

Porins
Transient Receptor Potential Channels
Calcium

Grants and funding

HHMI/Howard Hughes Medical Institute/United States